Fig. 7
From: Stereochemical conversion of nucleic acid circuits via strand displacement
A proposed solution to overcome signal degradation. a Conventional molecular operations for the detection of genetic material and for the conversion of an RH-input (T2) to an LH-output (T3). A concern with this design is the potential for inadvertent binding of T2 with background genetic materials. b A solution to the concern in a. Integration of molecular converter with sensor into a single unit bypasses the first step, in the production of T2, and goes directly to producing T3. c Depiction of the various components involved in b. Blue: LH-γPNA, green: RH-γPNA, T1: DNA or RNA target. Orthogonal nucleobases could be incorporated in domain a of “Waste” product to prevent its hybridization to domain a’ of H1B. Circle: PEG-spacer
