Fig. 1 | Communications Chemistry

Fig. 1

From: Stereochemical inversion as a route to improved biophysical properties of therapeutic peptides exemplified by glucagon

Fig. 1

Summary of physical and in vitro biological properties of the glucagon analogs. a Solubility in PBS of the glucagon analogs with single d-amino acid substitution with standard deviation. b Amyloid-like fibril formation in 0.1 N HCl as measured by Thioflavin-T fluorescence with standard deviation. c Percent in vitro potency of glucagon analogs relative to native hormone at the glucagon (red) and GLP-1 (green) receptors as determined by comparative EC50 values, and standard deviations reported in Table 1

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