Table 2 Conversion of 4,6-substituted-t-CMP derivatives into carbapenams

From: Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases

  1. See Fig. 8 for reaction scheme
  2. a% conversion by carbapenam synthetase catalysis, into 1,6-substituted-carbapenam-3-carboxylate (C3C) products was determined by LC–MS analysis measuring substrate conversion, in comparison with a control uncatalysed reaction. Rn = H, unless otherwise stated. (S)-stereocentres are in red and (R)-stereocentres are in blue, throughout, for positions 1 and 6
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