Fig. 3: The electroretinographic responses in rats treated with oxalate fibrils are similar to those observed in hyperoxaluria patients.
From: Induction of retinopathy by fibrillar oxalate assemblies
a Dark-adapted electroretinographic (ERG) responses elicited by flashes of different strengths, as denoted in log units to the left, are shown for each recording session. Arrow: time of light stimulus. Calibration bar: 200 µV. b Response-stimulus strength relationships for the dark-adapted ERG responses of the same rat. The curves were fitted to a hyperbolic type function. c The ratio between experimental and control Vmax of the ERG a-wave and b-wave at three time points, as indicated. Error bars: standard deviation of the mean. d, e The relationship between the ERG b-wave and a-wave amplitude was plotted for each response evoked in the dark-adapted state in hyperoxaluria patients and in model rats. In each frame, the light gray markers denote the relationship obtained in normal eyes. d Data obtained from 5 hyperoxaluria patients and 15 healthy controls. e Data from the experimental rat eyes treated with intravitreal injection of oxalate fibrils are illustrated for each recording session after the injection.
