Fig. 6: Superposition of views from crystal structures of FIH in complex with consensus ankyrin sequence peptides. | Communications Chemistry

Fig. 6: Superposition of views from crystal structures of FIH in complex with consensus ankyrin sequence peptides.

From: A human protein hydroxylase that accepts D-residues

Fig. 6

Superimposed structures of FIH with: a (L)-leucine (PDB: 4B7E; orange) and (D)-leucine (PDB: 4JAA; yellow-green) residues at the hydroxylation position. FIH atoms close to the substrates are in pink and cyan, for the (L)- and (D)-substrate views, respectively; b (L)-leucine; c (D)-leucine; d (2R,3S) 3-hydroxyleucine (PDB: 6RUJ; purple); e (D)-allylglycine (PDB: 4NR1; dark-green); f (L)-asparagine (salmon) and (D)-leucine (yellow-green); g (L)-asparagine (salmon) and h (L)-aspartate (PDB: 2XUM); slate-blue). Note that hydrogens are shown on the side chains of the substrate residues in the non-superimposed structures.

Back to article page