Fig. 1: Phosphine ligand influence on a palladium-catalyzed stereoselective Suzuki–Miyaura coupling to generate the stereoinversion product (2-Z) or stereoretention product (2-E). | Communications Chemistry

Fig. 1: Phosphine ligand influence on a palladium-catalyzed stereoselective Suzuki–Miyaura coupling to generate the stereoinversion product (2-Z) or stereoretention product (2-E).

From: Data-science driven autonomous process optimization

Fig. 1

aConditions: 10 µmol 1-E, 1 µmol 1,3,5-trimethoxybenzene, 20 µmol (3-(benzyloxy)phenyl)boronic acid 3, 0.4 µmol Pd(ACN)2Cl2, 30 µmol K3PO4 (0.5 M aq) in ACN (0.05 M), 2 h at 25 °C. b,cConditions: 10 µmol 1-E, 1 µmol 1,3,5-trimethoxybenzene, 11 µmol (3-(benzyloxy)phenyl)boronic acid 3, 0.2 µmol Pd(ACN)2Cl2, 0.4 µmol L, 30 µmol K3PO4 (0.5 M aq) in ACN (0.05 M), 2 h at 25 °C. Ligand structures are provided in Fig. 4. Tabulated results are provided in Supplementary Information Table SI-9.

Back to article page