Fig. 4: Parameters and results of optimization with ligands selected through chemical intuition in campaign 1.

Conditions: 10 µmol 1-E, 1 µmol 1,3,5-trimethoxybenzene, 10–20 µmol (3-(benzyloxy)phenyl)boronic acid 3, 0.1–0.5 µmol Pd(ACN)₂Cl₂, 0.05–2 µmol L, 30 µmol K₃PO₄ (0.5 M aq) in ACN (0.05 M), 2 h at 10–40 °C. Tabulated results are provided in Supplementary Information Table SI-10.