Fig. 3: Hydrophobic interactions involved in ligand binding. | Communications Chemistry

Fig. 3: Hydrophobic interactions involved in ligand binding.

From: The making of a potent L-lactate transport inhibitor

Fig. 3

Ligands A 1OHN2C, B N2C, C 3PP, and D 2M3PP as determined by structural analysis21. Hydrophobic residues within a distance of 4 Å from the bound compounds are displayed as ball-and-stick models and highlighted in cyan. The centers of benzene rings of aromatic residues and inhibitors, which are involved in π–π stacking interactions, are indicated by pink spheres. Distances are given in Ångström (Å). E–H Surface representations of the inhibitor binding site region. Bound compounds are displayed as ball-and-stick models. A cavity between TMs 7 and 10 is indicated by a black curved line and a star. PDB IDs of displayed structures are 6ZGR (1OHN2C), 6ZGS (3PP), 6ZGT (N2C), and 6ZGU (2M3PP).

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