Fig. 1: Quantifying homologous binding landscapes.
From: Quantifying the binding landscapes of protein–protein interactions
The effect of single and double mutations on the binding affinity of the cognate complex between bovine trypsin (BT) and BPTI is much more pronounced than for the homologous, non-cognate complexes between chymotrypsin (CT)-BPTI and mesotrypsin (MT)-BPTI. Reprinted with permission from J. Am. Chem. Soc. 142, 17261–17275 (2021). Copyright 2021 American Chemical Society.
