Fig. 1: Binding modes of FIIN-2, TAS-120 and PRN1371 to FGFR1 and SRC.
From: Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors
a Sequence alignment of the p-loop residues of kinase proteins. The position of the cysteine is indicated in red. b Chemical structures of FIIN-2, TAS-120 and PRN1371. c MALDI-TOF MS of apo FGFR1 (black) and FGFR1/inhibitor mixture (blue). d MALDI-TOF MS of apo SRC (black) and SRC/inhibitor mixture (blue).
