Fig. 5: Structural basis for SRC and FGFRs targeting by FIIN-2, TAS-120 and PRN1371.
From: Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors
The detailed interactions are shown in the structures of SRC/FIIN-2 (a), FGFR4/FIIN-2 (PDB ID: 4QQC) (b), SRC/TAS120 (c), FGFR1/TAS-120 (PDB ID: 6MZW) (d), FGFR4/PRN1371 (e) and modeled SRC/PRN1371 (f). The modeled SRC/PRN1371 structure was acquired by a superposition of SRC/FIIN-2 structure with the FGFR4/PRN1371 structure. Hydrogen bond is shown as black dotted lines. SRC is colored gray; FGFR1 is colored green; FGFR4 is colored pink; FIIN-2 is shown as salmon stick; TAS-120 is shown as yellow stick; PRN1371 is shown as cyan stick.
