Table 1 Thermodynamic parameters for association of H3K4me3 and H3KP4me3 peptides (ART(Kme3/KPme3)QTARKS) with five human reader domainsa.
From: Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins
H3K4me3 | H3KP4me3 | |||||||
|---|---|---|---|---|---|---|---|---|
Kd (μM) | ΔG° (kcal mol−1) | ΔH° (kcal mol−1) | -TΔS° (kcal mol−1) | Kd (μM) | ΔG° (kcal mol−1) | ΔH° (kcal mol−1) | -TΔS° (kcal mol–1) | |
KDM5APHD3 | 0.52 | −8.6 ± 0.1 | −10.4 ± 0.1 | 1.8 ± 0.1 | 0.20 | −9.1 ± 0.1 | −11.0 ± 0.1 | 1.9 ± 0.1 |
TAF3PHD | 0.11 | −9.5 ± 0.1 | −10.7 ± 0.1 | 1.2 ± 0.1 | 0.048 | −10.0 ± 0.1 | −11.1 ± 0.1 | 1.1 ± 0.1 |
BPTFPHD | 1.4 | −8.0 ± 0.1 | −12.5 ± 0.1 | 4.5 ± 0.1 | 0.20 | −9.1 ± 0.1 | −13.8 ± 0.1 | 4.7 ± 0.1 |
SGF29TTD | 3.2 | −7.5 ± 0.1 | −8.1 ± 0.1 | 0.6 ± 0.1 | 2.8 | −7.6 ± 0.1 | −8.6 ± 0.1 | 1.0 ± 0.1 |
KDM4ATTD | 3.5 | −7.4 ± 0.1 | −13.0 ± 0.1 | 5.6 ± 0.1 | 0.30 | −8.9 ± 0.1 | −17.7 ± 0.1 | 8.8 ± 0.1 |
