Fig. 4: Raman model generated using support vector machine (SVM) algorithm to differentiate.
From: Specific intracellular signature of SARS-CoV-2 infection using confocal Raman microscopy
A noninfected (Control, black) from measles virus (MeV, blue) infected Vero E6 cells, B noninfected (Control, black) from SARS-CoV-2 (red) infected Vero E6 cells, and C MeV and SARS-CoV-2-infected Vero E6 cells. The model was generated using Raman spectra extracted from intracellular components: cytoplasm (Cyto, square), Golgi-mitochondria bodies (Mito, circle), and nucleus (Noy, triangle) of the Vero E6 cells (Total accuracy A 98.89%, B 97.22%, C 97.78%, PCs used 13, tenfold CV other parameters same as below). The difference Raman spectra calculated between D control minus measles virus (MeV), E control minus SARS-CoV-2, and F Measles (MeV) minus SARS-CoV-2.
