Fig. 7: Influence of N-substituents on the production of 5-substituted hexahydro-1H-1,4-methanocarbazoles.

Reaction conditions: N-substituted 2-iodoaniline (1.0 eq.), NBE-5,6-diCOOiPr (1.0 eq.), morpholino benzoate (1.3 eq.), Pd(OAc)₂ (5% eq.), TFP (10% eq.), Cs₂CO₃ (2.5 eq.), toluene, 100 ^oC, 12 h.