Fig. 5: The double proton transfer tautomerisation reaction pathway.
From: Proton transfer during DNA strand separation as a source of mutagenic guanine-cytosine tautomers
a Double proton transfer tautomerisation as a function of separation distance and the reaction path image. b Demonstrating the changes in the reaction asymmetry as a function of the base separation distance. c The changes in the forward and reverse reaction barriers of the canonical to tautomeric double proton transfer scheme in G–C as a function of the imposed separation distance. The plotted barrier energy is the transition state energy referenced to either the canonical, tautomeric or intermediate (single proton transfer) stable state.
