Fig. 3: Substrate scope of cross-coupling using QMAs 4 and arenols 2a. | Communications Chemistry

Fig. 3: Substrate scope of cross-coupling using QMAs 4 and arenols 2a.

From: Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds

Fig. 3

Yields are those of isolated 5. aReaction conditions: 4 (0.065 mmol), 2 (3.2 equiv.), and TfOH (0.35 mol%) in degassed dry toluene/AcOEt (conc. of 4, 0.044 M, 10/1), micro mixer: β-type, flow rate: 0.068 mL/min, at 30 °C. bFlow rate: 0.055 mL/min, at 35 °C. cTfOH (0.5 mol%), flow rate: 0.048 mL/min, at 35 °C.

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