Fig. 3: PCA analysis of the fragment library employed in this study. | Communications Chemistry

Fig. 3: PCA analysis of the fragment library employed in this study.

From: Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

Fig. 3

The locations of the fragments identified in this screen (red triangles) and the fragments reported by Chimenti et al.26 (blue triangles) are highlighted. The hexagons (colored purple to yellow) indicate how many compounds were available in the library for a particular region of the chemical space. The dashed orange ellipse highlights the region where most of the fragments of both screens are located, indicating that these fragments share similar physicochemical parameters.

Back to article page