Fig. 4: Pharmacophore models derived from selected fragments binding to p97-N. | Communications Chemistry

Fig. 4: Pharmacophore models derived from selected fragments binding to p97-N.

From: Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

Fig. 4

Fragments of this study and from Chimenti et al.26 were superimposed with respect to similar chemical properties or recognition elements. Spheres represent similar functional groups present in both fragments. The chemical properties of the spheres are explained in the colour code (top left). The resulting pharmacophore models a–f are described in the main text.

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