Fig. 10: cATC derivatives 6e, 6j, and 6n inhibit tumor growth in vivo. | Communications Chemistry

Fig. 10: cATC derivatives 6e, 6j, and 6n inhibit tumor growth in vivo.

From: One-pot synthesis of cyclic-aminotropiminium carboxylate derivatives with DNA binding and anticancer properties

Fig. 10

4T1 cell derived tumor was induced in Balb/C mice and the animals were treated with 6e, 6j, and 6n compounds (1 mg/kg/day, 0.5 mg/kg/day, and 1 mg/kg/day, respectively) starting from day 8 till day 20, post tumor induction. A–C The representative images of mice with tumor. Right-hand side images show tumors from mice treated with cATC derivatives 6e (A), 6j (B) and 6n (C) and DMSO (control). Bar graphs (left) and line graph (middle) show average tumor mass and body weight in each group, respectively. Graphs in right show external tumor volume measured every alternative day. Each group had four animals. Values are mean ± SD; two-tailed unpaired Student’s t test was used for calculating P values; ns represents non-significant, * represents p-value ≤ 0.05, ** represents p-value ≤ 0.01, *** represents p-value ≤ 0.001 and, **** represents p-value ≤ 0.0001, N represents experiment replicates.

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