Fig. 6: MEK targets identified as having significantly shifted Tm in a fractionation experiment. | Communications Chemistry

Fig. 6: MEK targets identified as having significantly shifted Tm in a fractionation experiment.

From: Experimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays

Fig. 6

Volcano plots for a C_F_Φ and b nC_nF_E indicate MEK1 and MEK2 were the most significantly stabilized protein by each iMAATSA. Melting-curves with error bars (n = 3) for nC_nF_E of c MEK1 and d MEK2. Melting-curves for C_F_Φ of e MEK1 and f MEK2. The data points represent the results of replicate experiments (n = 3) for a, b. The error bars represent the standard deviation (n = 3) for c–f.

Back to article page