Fig. 5: Dose-response curves of Mpro inhibitors with WT, ΔP168, A173V, and ΔP168/A173V Mpro variants using the live cell Src-Mpro-Tat-fLuc assay with 4-fold serial dilution of inhibitor beginning at 10 µM (data are mean +/- SD of biologically independent triplicate experiments).

a Dose-response curves of CDD-1733. b Dose-response curves of CDD-1819. c Dose-response curves of CDD-1845. d Dose-response curves of CDD-1935. e Dose-response curves of Nirmatrelvir.