Fig. 1: Bivalent inhibitors of EGFR developed in this study and relevant ATP and allosteric analogues for functional comparisons. | Communications Chemistry

Fig. 1: Bivalent inhibitors of EGFR developed in this study and relevant ATP and allosteric analogues for functional comparisons.

From: Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Fig. 1

Chemical structures of bivalent ATP-allosteric inhibitors consisting of N-linked reversible (1) as well as C-linked reversible (2, 3) and covalent (4) scaffolds. Parent ATP-site imidazole reversible (5, 6) and covalent (7) inhibitors as well as dibenzodiazepinone allosteric inhibitors (8, 9).

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