Fig. 3: Contact interfaces between S6 helices at the gate region of rat TRPV1.
From: Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels
a – π-open-V1 state, b – π-closed-V1 state, c – α-closed-V1 state. The panels in each row from left to right: (1) Cylindrical projection of self MHP distribution over the surface of one S6-helix (residues 670-682). The areas of contact with neighbor S6-helices are marked by red curves, the positions of residues on the helix surface are marked on a map, cryo-EM protein structures listed in Table 1 are used for mapping. (2) Surface of the S6-helix fragment (residues 670-682) colored by its MHP values, the positions of residues on the helix surface are labeled. The helix fragment imposed on the two neighboring S6-helices in a cartoon representation. The pore-lining residues are noted by red letters and shown as sticks. (3) Cylindrical projection of 3D–1D profile scores of S6 helix residues 670-682: accessible surface of each residue is colored according to the score value. The coloring scheme is shown on the right. The areas of residue-residue contacts for neighbor S6 are marked with red contours.
