Table 1 The list of TRPV structures studied in this work
From: Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels
PDB ID | Description | Rgate, Å | S6-helix conformation | Naming in this work | Refs. | |
|---|---|---|---|---|---|---|
Rat TRPV1 minimal | 7L2W | RTX + NMDG bound open state | 2.9 | π-bulge | π-open-V1 | |
7L2P | Closed apo state | 0.6 | π-bulge | π-closed-V1 | ||
7MZC | RTX bound closed state | 1.0 | π-bulge | π-semiopen-V1 | ||
7MZD | RTX bound closed state | 0.5 | α-helix | α-closed-V1 | ||
7L2U | DkTx bound open state | 1.2 | α-helix | α-open-V1 | ||
Mouse TRPV3 | 7MIO | Open state at 42 °C | 2.8 | π-bulge | π-open-V3 | |
7MIN | Closed state at 42 °C | 0.9 | π-bulge | π-closed-V3 | ||
7MIL | Sensitized state at 42 °C | 1.7 | π-bulge | π-semiopen-V3 | ||
6PVL | Closed state at 42 °C | 0.7 | α-helix | α-closed-V3 | ||
Human TRPV6 | 7S88 | Open apo state | 2.9 | π-bulge | π-open-V6 | |
6E2F | Calmodulin bound closed state | 1.3 | π-bulge | π-closed-V6 | ||
7S8C | Econazole bound closed state | 0.7 | α-helix | α-closed-V6 |
