Fig. 3: Time-resolved structures for the analysis of the binding process of boric acid to CTX-M-14. | Communications Chemistry

Fig. 3: Time-resolved structures for the analysis of the binding process of boric acid to CTX-M-14.

From: Time-resolved crystallography of boric acid binding to the active site serine of the β-lactamase CTX-M-14 and subsequent 1,2-diol esterification

Fig. 3

Polder electron density (contoured at 5 σ, green mesh) of the active site Ser70, the sulfate ions and bound boric acid are shown at different delay time points after mixing microcrystals with boric acid. The 1 h soak structure was obtained with the TapeDrive after microcrystals have been soaked in boric acid for 1 h and shows that almost no further increase in electron density is observed after 10 s. BAB and GBE oxygen atoms are labeled in red. Potential hydrogen bond distances (Å) are indicated by dashed lines.

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