Table 1 Optimization of reaction conditionsaView full size image

From: Feedstock chemical dichloromethane as the C1 source for the chemoselective multicomponent synthesis of valuable 1,4,2-dioxazoles

Entry

Additive

Isolated yield (%)

1

DBU

63

2

Et3N

13

3

DIPEA

ND

4

DABCO

NR

5

Pyridine

NR

6

2,4,6-Collidine

ND

7

DMAP

ND

8

TBD

58

9

Cs2CO3

ND

10

KOtBu

ND

11b

DBU

72

12

-

NR

  1. ND not detected, NR no reaction.
  2. aReaction conditions: 1a (0.1 mmol), 2 (0.2 mmol), DBU (0.2 mmol) in DCM (1 mL) at 60 °C for 24 h under argon.
  3. b2 (0.25 mmol), DBU (0.25  mmol).
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