Table 1 Physicochemical parameters of BAPDiT and BAPDiS.[a]

From: Ca2+-triggered allosteric catalysts crosstalk with cellular redox systems through their foldase- and reductase-like activities

Compound ± metal ions

E°′ (mV) [b]

pKa1 [c], pKa2 [d] (pKaaverage) [e]

BAPDiT

− Ca2+

−378 ± 2

6.2 ± 0.1, 10.1 ± 0.1 (8.2)

+ Ca2+

−296 ± 2

6.9 ± 0.2, 9.3 ± 0.1 (8.1)

+ Mg2+

−386 ± 1

ND [f]

BAPDiS

− Ca2+

−383 ± 1

ND [f]

+ Ca2+

−351 ± 2

ND [f]

DTT

− Ca2+

−327

9.2, 10.1 (9.7) [g]

DST

− Ca2+

−396 ± 7 [h]

ND [f]

  1. [a]All data are shown as the mean ± standard error mean (SEM) (n = 3). [b]Reduction potential calculated using the Nernst equation with a DTTred reduction potential of −327 mV68. Experiments were performed as previously described23. [c]Acid dissociation constant of the first thiol. [d]Acid dissociation constant of second thiol. [e]Average pKa1 and pKa2. [f]Not determined. [g]Data from ref.69. [h] Data from ref. 23.