Table 1 PPII helix-substituted aPP analogs (7−18) synthesized on solid support (X = ΔaPro)
From: Stabilization of a miniprotein fold by an unpuckered proline surrogate
Peptide | Sequence (X = ΔaPro) | Calculated m/z | Observed m/z | Yield % |
|---|---|---|---|---|
| ||||
7 | GPSQPTYPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 2118.5471 [M + 2H]2+ | 2118.5485 [M + 2H]2+ | 8 |
8 | GXSQPTYPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 1412.3628 [M + 3H]3+ | 1412.3613 [M + 3H]3+ | 6 |
9 | GPXQPTYPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 1062.5310 [M + 4H]4+ | 1062.5319 [M + 4H]4+ | 6 |
10 | GPSXPTYPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 2102.5367 [M + 2H]2+ | 2102.5354 [M + 2H]2+ | 7 |
11 | GPSQXTYPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 1412.3621 [M + 3H]3+ | 1412.3613 [M + 3H]3+ | 8 |
12 | GPSQPXYPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 2116.0401 [M + 2H]2+ | 2116.0408 [M + 2H]2+ | 6 |
13 | GPSQPTXPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 1390.3584 [M + 3H]3+ | 1390.3578 [M + 3H]3+ | 14 |
14 | GPSQPTYXGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 1412.0305 [M + 3H]3+ | 1412.0295 [M + 3H]3+ | 3 |
15 | GPSXPXYPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 2101.0354 [M + 2H]2+ | 2101.0335 [M + 2H]2+ | 13 |
16 | GPSPPTYPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 2103.0461 [M + 2H]2+ | 2103.0456 [M + 2H]2+ | 10 |
17 | GPSQPPYPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 1412.0401 [M + 3H]3+ | 1412.0374 [M + 3H]3+ | 7 |
18 | GPSGPTYPGDDAPVEDLIRFYDNLQQYLNVVTRHRY | 2103.0461 [M + 2H]2+ | 2103.0456 [M + 2H]2+ | 10 |
