Fig. 1: Chemical structures of benzene (1), cubane (2), and cyclooctatetraene (3) and its valence isomers.

Bond distances are given in Å and taken from ref. ^54,55,56. Substituted aromatic moieties have been used for the selection of SOMAmers⁴³, cubane 2 and substituted analogs are present in cubamers^33,51, and carboxylated COT 3 has been used in this article.