Fig. 2: Effect of LUVs on different Aβ(1-42) aggregation kinetic parameters. | Communications Chemistry

Fig. 2: Effect of LUVs on different Aβ(1-42) aggregation kinetic parameters.

From: Ganglioside GM1 slows down Aβ(1-42) aggregation by a primary nucleation inhibitory mechanism that is modulated by sphingomyelin and cholesterol

Fig. 2

Lipid-induced changes to the half-times (a) lag-times (b), and growth-times (c) of Aβ(1-42) aggregation reported relative to the kinetics in buffer (absence of large unilamellar vesicles (LUVs)). Each group of bars represent consecutively 2, 20, 50, and 100 μM (lipid equivalents) of the indicated LUV type. The data were extracted from the kinetic curves in Fig. S6 as defined in (d) and further described in the Methods section. d Schematic illustration of the definition of half-time, lag-time, and growth-time as plotted in (a–c). e Correlations of lag-times or growth-times with half-times for all data shown in (a–c), calculated with Pearson’s correlation coefficient (PCC). Error bars represent standard deviation of three technical replicates (n = 3).

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