Fig. 8 | Communications Physics

Fig. 8

From: A statistical approach to detect protein complexes at X-ray free electron laser facilities

Fig. 8

Hit-finding performance of simulated hits superimposed on real background. Three representative spherical particle sizes (8, 13, 40 nm) were simulated for varying pulse intensities, particle sizes, focal properties, and hit-finding methods. We present our hit-finding method and a simpler scheme using our derived pixel mask and the total expected photon count given the pulse energy. Hit-finding was also performed in three distinct beam settings: particles hit perfectly on focus by a tophat beam (a) and the more realistic cases of a Lorentzian or a Gaussian beam hitting the particle (b and c). In all the plots, normalized scores are shown as a solid line, whereas photon count based detection is dash-dotted. For the most interesting cases of a 13 nm particle hit by a Lorentzian and Gaussian beam, we found a 50% recovery, respectively, at intensities of 2.10 × 1013 photons × pulse−1 × μm−2 and 9.73 × 1013 photons × pulse−1 × μm−2 with our statistical hit-finder; at 4.61 × 1013 photons × pulse−1 × μm−2 and 2.12 × 1014 photons × pulse−1 × μm2 with the pure photon-based one

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