Fig. 5

Implementation of Biological Physically Unclonable Function (Bio-PUF). a A standard cameraman image (© 1994–2019 The MathWorks, Inc) is introduced as a challenge (C) to 15 different Bio-PUFs (Xi, i = 1, 2, 3…, 15) and the corresponding responses are generated using logical XOR operation. b Color map of correlation coefficient and c inter-Hamming distance (Hinter) among these 15 responses. d 15 unique challenges (Ci, i = 1, 2, 3…, 15) applied to the same Bio-PUF (X) to generate the corresponding responses. (© 1994–2019 The MathWorks, Inc). e Color map of correlation coefficient and f Hinter among these 15 responses. In both instances no correlation is observed among the responses, as well as mean Hinter was found to be ~32, reasserting the uniqueness and unclonability aspects of Bio-PUF