Fig. 1: Protein conformations.

A Illustration of conformations of dilute protein monomers in the solvent and those packed in the suggested core-shell structure of the clusters. The blue color denotes more hydrophobic parts, but does not imply that these segments are folded. The black, hydrophilic domain of the proteins in the cluster core is more collapsed. B The interfacial layer consists of more hydrophilic protein segments that face the solvent and more hydrophobic segments that face the core.