Extended Data Fig. 3: The workflow of comparison between multiple classical explanations + Raman Experts and ComFilE.

a Eleven classical explanations were applied to the trained classifiers and calculated the heat maps. The Raman experts ranked the molecules as decreasing the possibility of markers, referring to heat maps and spectral database of molecules. b ComFilE was applied to trained classifiers, calculated delta accuracy, and ranked the molecules as the delta accuracy decreasing. c The evaluation of explanation efficacy.