Extended Data Fig. 5: Effect of CD38 trispecific Ab on T lymphocyte subset distribution in the blood of NHPs. | Nature Cancer

Extended Data Fig. 5: Effect of CD38 trispecific Ab on T lymphocyte subset distribution in the blood of NHPs.

From: Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation

Extended Data Fig. 5

Blood samples from animals (n = 3) treated with a single SC administration (100 ug/kg) were analyzed by flow cytometry to quantitate CD4, CD8, CD8 effector memory and T regulatory cells as indicated. CD4+ T cells were selected using cell surface staining for CD2 + /CD4 + /CD8-, CD8 + T cells with CD2 + /CD4-/CD8 + ; CD8 + effector memory by CD2 + /CD4-/CD8 + /CD45RA + /CD197- and regulatory T cells with CD2 + /CD4 + /CD8-/CD127-/CD25hi. The data were plotted as individual animals.

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