Extended Data Fig. 6: Effect of intra-animal dose escalation on serum levels and inflammatory cytokine release in NHP. | Nature Cancer

Extended Data Fig. 6: Effect of intra-animal dose escalation on serum levels and inflammatory cytokine release in NHP.

From: Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation

Extended Data Fig. 6

Animals (n = 3) were injected IV with the CD38 trispecific Ab at 10 ug/kg on day 1, 30 ug/kg on day 4, and 100 ug/kg on day 7. Serum samples were measured for trispecific Ab serum concentration using a Gyrolab immunoassay (Gyros Protein Technologies). Plasma samples were analyzed for inflammatory cytokines IL-6 and IFN-γ as described in Methods. The data were plotted as individual animals.

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