Extended Data Fig. 7: Cytolysis of the CD38 trispecific Ab of CD38+ hematological cancer cell lines. | Nature Cancer

Extended Data Fig. 7: Cytolysis of the CD38 trispecific Ab of CD38+ hematological cancer cell lines.

From: Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation

Extended Data Fig. 7

Cytolytic activity of the CD38/CD28xCD3 trispecific FALA mutant Ab against indicated CD38+CD28- lines, including acute myelocytic leukemia (AML (KG-1)), a B cell lymphoma (OCI-Ly19), acute T lymphocytic leukemia (ALL (KOPN8)), and chronic lymphocytic lymphoma (CLL(Z-138)). The representative nonlinear regression graphs (ordinary fit) ± SD are from 2 PBMC donors performed in two separate experiments.

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