Extended Data Fig. 5: Landscape of genomic instability (GI) in African Americans (AAs) and European Americans (EAs) in 23 cancer types from The Cancer Genome Atlas (TCGA) cohort.

Here, GI is quantified and presented stratified by genetic ancestry for 23 cancer types where the sample size for each cancer type is provided on the x-axis. First, cancer types are categorized by cell type or tissue of origin, if possible, where defined groups are pan-squamous (squamous cell derived tumors), pan-adeno (glandular structures in epithelial tissue derived tumors), pan-kidney (tumors originating in the kidney), and rest (referring to cancer types that cannot be categorized and includes LAML, THYM, GBM, LGG, SARC, BRCA, LIHC, OV, TCGT, THCA and UCEC; Refer here for reference to each cancer type: https://gdc.cancer.gov/resources-tcga-users/tcga-code-tables/tcga-study-abbreviations). Second, additional categorization was performed based on tissue type (where solid is derived from solid tumors and neural-crest and Hema & Lymph—hematologic and lymphatic tumors). A two-sided Wilcoxon Rank-sum test has been performed within each cancer type and significance before multiple testing correction is provided. Here, in the box plot, the center line denotes the median, the box indicating the interquartile range and the black line represents the rest of the distribution, except for points that are determined to be “outliers”, 1.5 times the interquartile range.