Extended Data Fig. 9: Morphologic Features with Phylogenetic Patterns in Pancreatic Ductal Adenocarcinoma PAM32. | Nature Cancer

Extended Data Fig. 9: Morphologic Features with Phylogenetic Patterns in Pancreatic Ductal Adenocarcinoma PAM32.

From: A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma

Extended Data Fig. 9

(a) Phylogenetic analysis illustrating the clonal relationship of samples analyzed in this patient. The predicted timing of somatic alterations in driver genes and whole genome duplication are also shown. Purple outline indicates samples that have SD based on histology and immunolabeling (squares). Samples PT3-PT6 with SD are more closely related to each other than to other samples in the same patient. (b) Relationship of anatomic location to morphologic heterogeneity. One liver metastasis (PT7, not sequenced) showed GL morphology. (c) Representative histologic images of the primary and metastatic tumors in this patient (out of total 39 histologic images for PAM32). Scale bar: 100um.

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