Extended Data Fig. 3: Pretreatment tumor mutational burden is not significantly correlated with response to chemoradiation or consolidation immune checkpoint inhibition (CICI).

Pretreatment tumor mutational burden in non-synonymous mutations per megabase extrapolated from CAPP-Seq in (a) patients with ctDNA detected (n=26) and not detected (n=25) after chemoradiation therapy and (b) patients with ctDNA increasing early on-CICI (n=5) and decreasing early on-CICI (n=5). P values were calculated using two-sided Mann-Whitney tests. Bars represent medians.