Extended Data Fig. 3: Clonal relatedness in tumor infiltrating T cells and PBMC.
From: Immune awakening revealed by peripheral T cell dynamics after one cycle of immunotherapy
a Clonal relatedness changes in PBMC-private and TIL-private TCR pools; comparison of week 3 (W3) CDR3 clonal relatedness in patients with progressive disease (PD, n=11 patients) and disease control at week 12 (DC, n=7 patients) in the PBMC-private (P=0.724, median=0.6x10−6 and 0.6x10-6, respectively; two-sided Mann-Whitney U test) and TIL-private pools (P=0.246, median= 0.5x10-4 and 0.8x10-5, respectively; two-sided Mann-Whitney U test). Dot represents one patient; green indicates DC; orange indicates PD; error bar is standard deviation.
