Extended Data Fig. 5: Additional analysis of Myc function in an allograft model of bone metastasis. | Nature Cancer

Extended Data Fig. 5: Additional analysis of Myc function in an allograft model of bone metastasis.

From: A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance

Extended Data Fig. 5

a, Bar graphs and crystal violet staining of colony formation assays of NPK bone cells two weeks after treatment with shControl or shRNAs targeting Myc (shMyc#1 and shMyc#2). b, Comparison of lung and bone from Nude mouse hosts implanted via intracardiac injection with green fluorescent protein (GFP)-tagged cells derived from primary tumors of non-metastatic NP mice (NPGFP cells, reported in;16 n = 2) or the NPKEYFP bone cells (n = 10). Shown are representative ex vivo fluorescence or H&E images. Scale bars represent 0.1 cm for the ex vivo fluorescence images and 50 μm for all other images.

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