Extended Data Fig. 4: Further characterization of patient-specific DNA methylation changes.

a, Variability of DNA methylation changes measured by the interquartile range (IQR) in normal and neoplastic B cells against the median number of DNA methylation changes per each subtype. R and p-values were derived from linear modelling. Shaded area represents 95% confidence interval. b, Correlations in all B cell tumors between B-cell independent DNA methylation changes and B-cell related changes for hypermethylation (top) and hypomethylation (bottom) changes. R and p-values were derived from linear models. c, Number of B-cell related or B-cell independent hyper- or hypomethylation in B-cell tumors showing consistent patterns (Methods). d, B-cell independent CpGs losing DNA methylation in B-cell tumors and the percentages of each chromatin state in normal and neoplastic B-cells. The mean of percentages per sample type is shown. The sample sizes are the same as in Fig. 4c and also apply for panel g. e, The mean of 2,000 representative CpGs per each sample subtype from panel d is represented. f, Gene density distributed along the expression percentiles of genes associated with B-cell independent CpGs losing DNA methylation at low signal heterochromatin in B-cell tumors. Expressed genes (H3K36me3) are displayed at right as control. Means within each B-cell subpopulation as well as B-cell tumors are represented. g, B-cell independent CpGs gaining DNA methylation in B-cell tumors and the percentages in each chromatin state in normal and neoplastic B-cells. h, The mean of 2,000 representative CpGs per each sample subtype from panel g is represented. i, Gene density distributed along the expression percentiles of genes associated with B-cell independent CpGs gaining DNA methylation at H3K27me3 regions in B-cell tumors. Expressed genes (H3K36me3) are displayed at right as control. Means within each B-cell subpopulation as well as B-cell tumors are represented. Sample size for DNA methylation analyzes in panels a, b, c, e and h are the same as in Fig. 4a. Samples sizes for gene expression analyses in panels f and i are the same as in Fig. 4e.