Extended Data Fig. 2: PARP inhibition modulates the tumor microenvironment and increases intratumoral macrophages in BRCA1-deficient TNBC.
Mice bearing BRCA-deficient TNBC tumors were treated with either vehicle or 50 mg kg−1 of Olaparib for 5 days. a, Mice maintained their body weight during the treatment. b, Gating strategy for flow cytometry used throughout manuscript. c, Representative images of MAC2 immunohistochemistry, percentage of positive cells were assessed using ImageJ quantification (n = 6 mice). Representative images are shown at 20x magnification and are representative of the 6 mice. Error bars represent standard error of mean (±SEM). Statistical analyses were performed using one-tailed t-test. Exact p values indicated in each panel for each comparison.
