Extended Data Fig. 6: Distribution of cell neighbourhoods by molecular subtypes of breast cancer.

tSNE reference maps representing cell types as light grey makers (tSNE map based on median marker expression values derived from n = 479, 844 cells). Neighbourhood enrichment for each cell type within tumour molecular subtypes was determined by fitting a linear model taking mean neighbourhood values as the dependent variable and tumour molecular subtype as independent variable. Coloured markers indicate those significantly enriched within a given subtype (p-value < 0.05). Dark grey background is proportional to the point estimate from the linear model, providing an indication of the strength (size) of the association.