Extended Data Fig. 8: Single cell transcriptomics defines distinct expression signatures in primary B-ALL cells.

a, Clustering of bone marrow cells from a prednisolone sensitive patient (n = 2,427 control cells; n = 924 treated cells) based on top 1000 most highly expressed genes b, Identification of distinct cell populations in a prednisolone sensitive patient CD19 + B-cells (red), CD3E + T-cells (blue), ALAS2 + Erythrocytes (purple) and CD14 + Macrophages (green) c, Control vs. treatment for all cell clusters in prednisolone sensitive patient (red = control, blue = treated) d, Clustering of bone marrow cells from a prednisolone resistant patient (n = 686 control cells; n = 759 treated cells) based on top 1000 most highly expressed genes e, Identification of distinct cell populations in a prednisolone resistant patient CD19 + (red) and CD3E + T-cells (blue) f, Control (C) vs. treatment (T) for all cell clusters in prednisolone resistant patient (red = control, blue = treated).