Extended Data Fig. 6: STAU2 targets genes identified by eCLIP Analysis. | Nature Cancer

Extended Data Fig. 6: STAU2 targets genes identified by eCLIP Analysis.

From: An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia

Extended Data Fig. 6

a, Z-scores of individual k-mers from Stau2 eCLIP (in the CDS, the UTRs and introns). b, Motifs identified by HOMER analysis of Stau2 eCLIP peaks located within different annotated regions. c, Violin plot of the average base pairing probabilities across each reproducible STAU2 peak and their flanking regions. The swarmplot of light-blue dots represent median values of 100 iterations of random shuffled base pair probability means to show significance (compared to the white dots showing actual median bpp). d, Metagene diagram showing the pattern of significant binding across a generic mRNA transcript. e, eCLIP traces showing STAU2 binding peaks in the indicated 3’UTR regions of GFER and NRAS and in the CDS of KDM1A.

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