Extended Data Fig. 9: Meta-analysis of EIF5B expression correlated with survival across lung cancer datasets.
From: eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer
a, Oncoprint plot depicting mRNA upregulation, amplifications, and mutations in EIF5B in human lung adenocarcinoma samples from the TCGA, Firehose Legacy. b, Kaplan-Meier survival analysis of patients with or without EIF5B alterations shown in (a) from the TCGA Firehose Legacy lung adenocarcinoma study using cBioPortal. n = 230 patients, Log rank test p-value = 0.0238. c, Summary of meta analyses results. d, Forest plot of meta-analysis showing association between EIF5B mRNA expression and patient survival outcome in all lung cancer patients across different studies (26 studies with 4,528 patients in total). e, Forest plot showing association between EIF5B expression and patient outcome in lung adenocarcinoma patients across different studies (20 studies with 2,882 patients in total). f, forest plot showing no association between EIF5B and patient survival in lung squamous cell carcinoma patients (26 studies with 1,277 patients in total). The confidence interval was calculated based on two-sided tests.
