Extended Data Fig. 5: Rel gene deletion in macrophages results in decreased expression of inflammatory genes.
From: c-Rel is a myeloid checkpoint for cancer immunotherapy
BMDMs from WT and Rel−/− mice were treated with vehicle or LPS (100 ng/mL) for 1 hour and gene microarray analysis was performed for ~30,000 murine genes. Ingenuity Pathway Analysis was performed to identify c-Rel-regulated genes that were downstream of LPS response. Blue genes were decreased, and red genes were increased in Rel−/− cells as compared to WT cells, after LPS treatment.
