Extended Data Fig. 4: Enrichment of biological processes and protein complexes in the top OncodriveFML (OFML) hits. | Nature Cancer

Extended Data Fig. 4: Enrichment of biological processes and protein complexes in the top OncodriveFML (OFML) hits.

From: Multi-omic analysis reveals significantly mutated genes and DDX3X as a sex-specific tumor suppressor in cutaneous melanoma

Extended Data Fig. 4

a and b, Left panel: gene set membership for 66 genes which had an OFML FDR < 10%. Right panel: P-values from a one-tailed Fisher’s exact test of the overlap of Reactome (a) or EpiFactors (b) gene sets with genes that passed an OncodriveFML FDR of <10%. Only gene sets that passed an FDR threshold of <20% are shown. FDRs were computed form p-values using the Benjamini-Hochberg procedure. c, Bar plot showing the frequency of somatic mutations in (SWI/SNF)/BAF complex subunits (ARID2, ARID1A, ARID1B, BRD7, and PBRM1) and MLL complex subunits (KMT2A, KMT2B, KANSL1, and MEN1) that passed an OncodriveFML FDR of <10%. Number of samples = 1,014 tumors.

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